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Paper Title : Effect of probiotic-fermented milk supplemented with carob pods on ethanol induced-ulcer in rats
ISSN : 2395-1303
Year of Publication : 2022
MLA Style: -Sana M’hir, Kais Rtibi, Haifa habibi, Rym sassi, Lamia Ayed, Lamjed Marzouki, Hichem Sebai , Effect of probiotic-fermented milk supplemented with carob pods on ethanol induced-ulcer in rats" " Volume 8 - Issue 1 January - February,2022 International Journal of Engineering and Techniques (IJET) ,ISSN:2395-1303 , www.ijetjournal.org
APA Style: - Sana M’hir, Kais Rtibi, Haifa habibi, Rym sassi, Lamia Ayed, Lamjed Marzouki, Hichem Sebai " Effect of probiotic-fermented milk supplemented with carob pods on ethanol induced-ulcer in rats " Volume 8 - Issue 1 January - February,2022 International Journal of Engineering and Techniques (IJET) ,ISSN:2395-1303 , www.ijetjournal.org
The aim of this study was to test the effect of milks enriched with carob and fermented by two probiotic strains, separately, Lactobacillus rhamnosus LGG and Lactobacillus casei LCS, against ethanol-induced gastric ulcer in rats, as well as the associated disturbances. These beverages were orally administered to animals on a daily basis for one week. On day 7, two hours after the last treatment, the animals were intoxicated for one hour with a single dose of 80% ethanol. The famotidine was used as the positive control at a dose of 10 mg/kg and the untreated group received distilled water at 10 ml/kg. The animals were sacrificed and the stomachs were cut opened to observe and calculate the ulcer index. The ulcer index was determined and percentage of protection was calculated. The associated alterations in the gastric mucosa were analyzed by colorimetric methods. A single dose of ethanol (80%) caused major bleeding lesions and was accompanied by altered cellular mediators. However, the pretreatment of the animals with a mixture probiotic fermented milk and carob has led to a greater gastroprotective action than that observed after the individualized administration of these products. Mixture such carob and pobiotic can be suggested as functional food to protect against gastric ulcer.
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Abbreviations Ca: Carob CS :Lactobacillus casei CS-ca: Lactobacillus casei-carob FMGG: Fermented Milk Lactobacillus rhamnosus FMGG-ca: Fermented Milk Lactobacillus caseicarob FMCS: Fermented Milk Lactobacillus casei FMCS-ca: Fermented Milk Lactobacillus caseicarob FM: Fermented milk GG: Lactobacillus rhamnosus GG-ca: Lactobacillus rhamnosus-carob M: Milk NSAIDs non-steroidal anti-inflammatory drugs
-Milk, carob, probiotic, functional fermented milk, gastric ulcer.